Laser application of nanocomposite hydrogels on cancer cell viability

Danyuo, Yiporo
Salifu, A. A.
Ani, C. J.
Dozie-Nwachukwu, S.
Ezenwafor, Theresa
Yirijor, J.
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MRS Advances
Nanocomposite hydrogels of poly-n-isopropyl were prepared by incorporating gold and magnetite nanoparticles. The nanocomposite-based hydrogels formed were geometrical, ~7.3 mm in diameter and 5 mm thick (in the swollen state). Morphological analysis was characterized by a scanning electron microscope. Drug-loaded hydrogels were subjected to laser heating at 1 W, 1.5 W and 2 W for 20 min in each laser cycle. The metabolic activities of the cells were analysed. The photothermal conversion efficiency of the nanocomposite hydrogels was also evaluated for P(NIPA)-AuNP-PG and P(NIPA)-MNP-PG to be 36.93 and 32.57 %, respectively. The result was then discussed for potential applications whereby metalbased hydrogels can be employed in microfluidic devices for targeted cancer drug delivery.
This is the Accepted Manuscript version of this article which has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Materials Research Society or Cambridge University Press, in MRS Advances published by Materials Research Society and Cambridge University Press, together with a copyright notice in the name of the copyright holder (Materials Research Society). On publication, the full bibliographical details of the article (volume: issue number (date), page numbers) will be inserted after the journal-title, together with a link to the Cambridge website address for the Journal
nanacomposite materials, hydrogels, cancer treatment