Laser application of nanocomposite hydrogels on cancer cell viability

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dc.contributor.authorDanyuo, Yiporo
dc.contributor.authorSalifu, A. A.
dc.contributor.authorAni, C. J.
dc.contributor.authorDozie-Nwachukwu, S.
dc.contributor.authorEzenwafor, Theresa
dc.contributor.authorYirijor, J.
dc.date.accessioned2020-04-24T11:46:14Z
dc.date.available2020-04-24T11:46:14Z
dc.date.issued2020
dc.descriptionThis is the Accepted Manuscript version of this article which has been accepted for publication and will appear in a revised form, subsequent to peer review and/or editorial input by Materials Research Society or Cambridge University Press, in MRS Advances published by Materials Research Society and Cambridge University Press, together with a copyright notice in the name of the copyright holder (Materials Research Society). On publication, the full bibliographical details of the article (volume: issue number (date), page numbers) will be inserted after the journal-title, together with a link to the Cambridge website address for the Journalen_US
dc.description.abstractNanocomposite hydrogels of poly-n-isopropyl were prepared by incorporating gold and magnetite nanoparticles. The nanocomposite-based hydrogels formed were geometrical, ~7.3 mm in diameter and 5 mm thick (in the swollen state). Morphological analysis was characterized by a scanning electron microscope. Drug-loaded hydrogels were subjected to laser heating at 1 W, 1.5 W and 2 W for 20 min in each laser cycle. The metabolic activities of the cells were analysed. The photothermal conversion efficiency of the nanocomposite hydrogels was also evaluated for P(NIPA)-AuNP-PG and P(NIPA)-MNP-PG to be 36.93 and 32.57 %, respectively. The result was then discussed for potential applications whereby metalbased hydrogels can be employed in microfluidic devices for targeted cancer drug delivery.en_US
dc.description.sponsorshipPan-African Materials Institute (PAMI) (Grant No. P126974) - funding. Ashesi University, Ghana Worcester Polytechnic Institute (WPI) USAen_US
dc.identifier.otherDOI:10.1557/adv.2020.193
dc.identifier.urihttp://hdl.handle.net/20.500.11988/537
dc.language.isoenen_US
dc.publisherMRS Advancesen_US
dc.subjectnanacomposite materialsen_US
dc.subjecthydrogelsen_US
dc.subjectcancer treatmenten_US
dc.titleLaser application of nanocomposite hydrogels on cancer cell viabilityen_US
dc.typeAccepted manuscript versionen_US

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